Asymmetric Cyclization Using Rhodium ( I) with Chiral Ligand 手性铑(I)配合物催化的不对称环化反应
Coordination occurred between ligands and transition metal in asymmetric hydrogenation, but their relationship may not be chelating or not chelating dominant, for that chelation can significantly improve the asymmetric induction activity of the ligand. 在不对称氢化过程中配体和过渡金属发生了配位,但其配位关系可能不是螯合的或者不是螯合占主导地位,因为普遍认为螯合作用能显著提高配体的不对称诱导活性。
Then, we also investigated asymmetric catalysis of this reaction, a variety of types of chiral phosphine ligand were tested, and the highest ee value is40%. 随后,我们又考察了反应的不对称催化,尝试了多种手性膦配体,其中ee值最高达到了40%。